Preheat the Oven: Preheat your oven to 400°F (200°C) and line a baking sheet with parchment paper.
Prepare the Chicken: In a mixing bowl, combine the flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper. Mix well.
Dunk the Chicken: In another bowl, whisk together the eggs and buttermilk. Dip each chicken tender into the egg mixture, allowing any excess to drip off, then dredge in the flour mixture, pressing to coat.
Fry the Chicken: Heat oil in a skillet over medium-high heat. Once hot, carefully add the breaded chicken tenders in batches, frying until golden brown and cooked through (about 3-4 minutes per side). Remove and place on the prepared baking sheet.
Make the Hot Honey Sauce: In a small saucepan, combine the honey, hot sauce, and red pepper flakes (if using). Heat over low until warmed through, stirring to combine.
Drizzle the Sauce: Once the chicken tenders are cooked, remove them from the oven and drizzle the hot honey sauce generously over each tender.
Serve: Serve the hot honey chicken tenders immediately with your favorite dipping sauces.